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Minerals · October 30, 2026

One in nine Korean adults with diabetes had low blood magnesium, and two routine lab numbers pointed to the people most likely to have it

Magnesium isn't part of the usual blood panel, so a low level often goes unseen. A national survey of 5,798 Korean adults found it four times as often in people with diabetes, and about one in five of those whose HbA1c was 8% or higher or whose kidney filtration had dropped below 60. Their diets weren't the obvious culprit.

Four blood collection tubes with grey, purple and red caps standing in a white rack, one labelled as a glucose tube
Photo: Frankincense Diala, Laboratory Test Tubes, from a medical laboratory in Abuja, Nigeria, 2023. CC0, via Wikimedia Commons. Cropped and resized.

Magnesium works behind the scenes in more than 600 of the body's enzyme reactions, including the ones that handle glucose and insulin. Diabetes and magnesium have an awkward relationship: high blood sugar makes the kidneys let more magnesium go, and too little magnesium makes insulin work less well. Yet serum magnesium is not on the standard blood panels most people with diabetes get, so few of them ever have it checked.

A study published in the Journal of Clinical Medicine on 20 October asks two practical questions: how common is low blood magnesium in people with diabetes across a whole country, not just in hospital clinics, and which of them would be worth testing? It uses the 2024 Korea National Health and Nutrition Examination Survey, the first round of that national survey to measure serum magnesium. After leaving out pregnant women and anyone without a magnesium result, 5,798 adults aged 19 and over remained, 959 of them with diabetes.

Low magnesium, defined as below 0.75 mmol/L (the usual lower limit of the reference range), turned up in 10.7% of adults with diabetes, against 2.4% of adults without it. People with diabetes made up 14.3% of the adult population but 41% of everyone with a low result. Scaled up to the country, that is an estimated 651,000 Korean adults with diabetes and low blood magnesium. The figure is lower than hospital studies suggest, where 20% to 40% is common, because those studies see sicker patients.

The risk wasn't spread evenly. Among people with diabetes, 22.5% of those with an HbA1c of 8% or more had low magnesium, compared with 9.2% of those under 7%. It was 21.3% in those whose estimated kidney filtration rate (eGFR) was below 60, against 9.9% above it. Put together, people meeting either mark made up 17.6% of adults with diabetes but 35.7% of the low-magnesium cases: testing them would find a low result in 21.7% of tests, about twice the hit rate of testing everyone with diabetes. Both numbers are already on most people's routine lab reports.

Low magnesium also went with worse health. After adjusting for age, sex, weight, income, diabetes medicines and kidney function, people with diabetes and low magnesium had about three times the odds of an HbA1c of 8% or more and twice the odds of protein leaking into the urine. They were also more likely to report depressive symptoms and tiredness, though the author calls those two links exploratory because they rest on few cases and weakened in some checks.

Diet didn't explain much. People with low magnesium ate less overall (1,661 against 1,918 kcal a day) and so took in less magnesium (302 against 348 mg), but the amount of magnesium per 1,000 kcal was almost the same. The author suggests magnesium lost through the kidneys matters more than what's on the plate, but urine magnesium wasn't measured, so that can't be confirmed. The study is a single snapshot, serum magnesium reflects less than 1% of the body's store, results were rounded to 0.1 mg/dL, and the survey had no data on diuretics or acid-reducing tablets that can lower magnesium. The author presents the testing rule as a preliminary proposal that needs checking in other populations. The work had no external funding and the author declared no conflicts of interest.

Analysis by NutroPractic from the sources listed. Written for general readers; it does not replace advice from your own doctor.

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