Eating behaviour · October 8, 2026
A three-year Mediterranean diet programme worked for weight loss. People with signs of food addiction lost as much at first, then gained much of it back
In a Spanish trial of 448 older adults with overweight and metabolic syndrome, a calorie-reduced Mediterranean diet with exercise and coaching eased food addiction symptoms and helped people lose weight. But those who met the food addiction criteria at the start had regained much of their year-one loss by year three; the others kept it off.

Some people describe their eating the way others describe an addiction: strong cravings, losing control around certain foods, carrying on despite wanting to stop. Researchers measure this with the Yale Food Addiction Scale, and a team in Spain wanted to know two things: can a long, intensive lifestyle programme ease those symptoms, and do people who score for food addiction do as well on the programme as everyone else? Their answer was published in BMC Medicine on 6 October 2026.
The study used 448 people from the cognition arm of PREDIMED-Plus, a large Spanish trial. They were 65 on average, carried extra weight and had metabolic syndrome. Half were randomly placed in an intensive programme: a Mediterranean diet with fewer calories, more physical activity and regular behavioural support. The other half, the control group, were advised to follow a Mediterranean diet with no calorie limit. Food addiction symptoms, weight, waist size, diet quality, activity and quality of life were measured at the start, after one year and after three years.
Food addiction scores fell in both groups, but the fall lasted only in the intensive group, which scored lower than the control group at three years. Among people without food addiction at the start, the intensive programme roughly tripled the odds of losing at least 8% of body weight and of trimming the waist by at least 5%, and it helped them stick to the diet far better. In that group, average weight in the intensive arm went from 86.3 kg to 80.2 kg after a year and was still 80.7 kg at three years. People in the intensive arm who did meet the food addiction criteria lost about as much in the first year (87.3 kg down to 81.6 kg), but were back up to 83.3 kg by year three, and their three-year loss was no longer statistically clear. Their waist and diet-quality gains were also smaller.
The authors' modelling suggests why: for people without food addiction, sticking closely to the diet carried through into lasting improvements in weight, waist and quality of life, but that link did not show up in people with food addiction. They argue that food addiction should be screened for and treated as a distinct profile in obesity care, with extra support aimed at cravings and loss of control. The analysis was a secondary look at one part of a larger trial, food addiction was self-reported on a questionnaire, and everyone was an older Spanish adult with metabolic syndrome, so the results may not carry over to younger or healthier people. At the time of writing the journal had posted the abstract and supplementary tables, with the full text to follow.
Three years on the programme
448
Older adults (average age 65) with overweight and metabolic syndrome, randomised to the intensive programme or a control group
2.9×
Higher odds of losing at least 8% of body weight in the intensive programme, among people without food addiction at the start
86.3 → 80.7 kg
Average weight over three years in the intensive group, people without food addiction
87.3 → 81.6 → 83.3 kg
Average weight at the start, one year and three years in the intensive group, people with food addiction
7.6 → 12.7
Mediterranean diet score after three years in the intensive group without food addiction (12.2 with food addiction; about 10 to 11 in the control group)
From the abstract and Additional File 1 (Table S1) of the open-access paper in BMC Medicine, published 6 October 2026: a secondary analysis of the PREDIMED-Plus Cognition sub-study (ISRCTN89898870). Weights are the descriptive group averages in Table S1 (434 participants analysed). Food addiction was measured with the Yale Food Addiction Scale 2.0. Funded by Spanish public research bodies (CIBEROBN and Instituto de Salud Carlos III, co-funded by the European Regional Development Fund) and others; one author reported consulting fees from Novo Nordisk, and other authors declared industry fees or research support.
- The Yale Food Addiction Scale 2.0, published in 2016, asks 35 questions that map eating onto the 11 symptoms the DSM-5 uses to diagnose substance use disorders, such as cravings, loss of control and carrying on despite problems.
- The control group in this trial was not left without advice: they were encouraged to eat a Mediterranean diet, just without calorie targets, exercise goals or intensive support. Their diet scores rose too, from about 7.8 to 10 or 11.
- People in the intensive group without food addiction raised their leisure-time physical activity by about half, from roughly 2,400 to 3,600 MET-minutes a week, and kept it there at three years.
- Targeting food addiction through an intensive energy-reduced Mediterranean diet lifestyle intervention: evidence from the 3-year PREDIMED-plus trialBMC Medicine, 6 October 2026 · Open access; abstract and supplementary Table S1 used for all study figures
- Development of the Yale Food Addiction Scale Version 2.0Psychology of Addictive Behaviors, 2016 · The questionnaire used to measure food addiction
- Grocery bag of junk foods (photo)US National Cancer Institute, via Wikimedia Commons · Public domain image
General information, not medical advice. Food addiction is not a formal diagnosis, and a questionnaire score is not a substitute for assessment by a professional. If you struggle with cravings or loss of control around food, talk to your doctor or a qualified dietitian about support before starting a weight-loss programme.
Analysis by NutroPractic from the sources listed. Written for general readers; it does not replace advice from your own doctor.
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